최해웅

Hae Woong Choi

 

Education

2008.8 – 2014.5          Ph.D.    Department of Pathology, Duke University, USA

2005.3 – 2007.2          M.S.     Division of Life Sciences, Korea University, Korea

1998.3 – 2005.2          B.S.      Division of Life Sciences, Korea University, Korea

 

Professional Experiences

2023.9 – Current          Associate Professor, Korea University, Korea

2019.9 – 2023.8           Assistant Professor, Korea University, Korea

2019.7 – 2019.8           Medical Instructor, Duke University, USA

2015.3 – 2019.6           Research Scientist, Duke University, USA         

2014.6 – 2015.2           Research Scholar, Duke University, USA

 

Locations & Contact

하나과학관 A동 513호(Office) 526호(Lab)

Tel. 3290-3412 (Office)

E-mail. haewoongchoi@korea.ac.kr

 

Publications

34. Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components.

Mencarelli A, Bist P, Choi HW, Khameneh HJ, Mortellaro A, Abraham SN

Nature Immunology. 2024 Mar 14. doi: 10.1038/s41590-024-01788-y.

 

33. Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity.

Hayes BW, Choi HW, Rathore AP, Bao C, Shi J, Huh Y, Kim HW, Mencarelli A, Bist P, Ng LG, Shi C, Nho JH, Kim A, Yoon H, Lim D, Hannan JL, Purves JT, Hughes Jr FM, Ji RR, Abraham SN.

Science Immunology, 2024 Mar;9(93):eadi5578. doi: 10.1126/sciimmunol.adi5578

 

32. Stabilization of Activated Mast Cells by ORAI1 Inhibitor Suppresses Peanut-Induced Anaphylaxis and Acute Diarrhea.

Suk G, Kwon DH, Roers A, Abraham SN, and Choi HW^† (^† Corresponding Author)

Pharmacological Research, 2023, Aug 11;106887. doi: 10.1016/j.phrs.2023.106887.

 

31. 요로감염세균의 감염기전과 이를 극복하기 위한 차세대 치료요법.

Choi HW^† (^† Corresponding Author)

Urology Digest, 2023, June 30. pp.51-56. Https://urodigest.com/articles/xml/GDxe/

 

30. α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidification.

Naskar M, Parekh VP, Abraham MA, Alibasic Z, Kim MJ, Suk G, Noh JH, Ko KY, Lee J, Kim C, Yoon H, Abraham SN, and Choi HW^† (^† Corresponding Author)

PLoS Pathogens, 2023 May 11;19(5):e1011388. doi: 10.1371/journal.ppat.1011388. 

 

29. Microbiome in urological diseases: Axis crosstalk and bladder disorders.

Choi HW, Lee KW, Kim YH

Investigative and Clinical Urology, 2023 Mar;64(2):126-139. doi: 10.4111/icu.20220357. 

 

28. The Urinary Microbiome: Role in Bladder Cancer and Treatment.

Friedrich V., and Choi HW^† (^† Corresponding Author)

Diagnostics, 2022, Aus 26: 12(9):2068. Doi: 10.3390/diagnostics12092068 

 

27. Lactobacillus crispatus Suppresses Bladder Uropathogenic E. coli Infection by Triggering a Host Type I Interferon Response. 

 

26. Enhancing adoptive T-cell therapy with fucoidan-based IL-2 delivery microcapsules.

Jeon EY, Choi D, Choi S, Won J, Jo Y, Kim H, Jung Y, Shin SC, Min H, Choi HW, Lee MS, Park Y, Chung JJ, Jin H

Bioengineering & Translational Medicine, 2022, July 4; e10362. DOI: 10.1002/btm2.10362. 

 

25. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury.

Lee B, Oh Y, Cho E, DiAntonio A, Cavalli V, Shin JE, Choi HW^†, Cho Y^† (^† Corresponding Author)

Journal of Biological Chemistry, 2022, Jan 29;298(3):101647. doi: 10.1016/j.jbc.2022.101647. 

 

24. Tumor-Associated Mast Cells in Urothelial Bladder Cancer: Optimizing Immuno-Oncology.

Choi HW , Naskar M, Seo HK, Lee HW

Biomedicines, 2021 Oct 20;9(11):1500. doi: 10.3390/biomedicines9111500. 

 

23. β-Defensin 2, an Antimicrobial Peptide, as a Novel Biomarker for Ulcerative Interstitial Cystitis; Can β-Defensin 2 Suspect the Dysbiosis of Urine Microbiota? 

Lee SW, Kim SH, Lee KW, Kim WB, Choi HW, Moon JE, Moon A, Kim YH

 

22. The Microbiome’s Function in Disorders of the Urinary Bladder. 

Choi HW, Lee KW, and Kim YH

 

21. Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens. 

Johnson-Weaver BT, Choi HW, Yang H, Granek JA, Chan C, Abraham SN, Staats HF

Frontiers in Immunology, 2021 Sep 10;12:730346. doi: 10.3389/fimmu.2021.730346. 

 

20. A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections.

Wu J, Hayes BW, Phoenix C, Macias GS, Miao Y, Choi HW, Hughes Jr FM, Purves JT, Reinhardt RL, Abraham SN.

Nature Immunology, 2020 Jun;21(6):671-683. doi: 10.1038/s41590-020-0688-3. 

 

19. Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury.

18. Novel mucosal adjuvant, mastoparan-7, improves cocaine vaccine efficacy.

 

17. A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions.

16. Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening.

Choi HW, Chan C, Shterev ID, Lynch HE, Robinette TJ, Johnson-Weaver BT, Shi J, Sempowski GD, Kim SY, Dickson JK, Gooden DM, Abraham SN, Staats HF.

SLAS Discovery, 2019 Jul;24(6):628-640.

 

15. MRGPRX2-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.

Arifuzzaman M, Mobley YR, Choi HW, Bist P, Salinas CA, Brown ZD, Chen SL, Staats HF, Abraham SN.

Science Advances, 2019 Jan 2;5(1):eaav0216.

 

14. Perivascular Dendritic Cells Elicit Anaphylaxis by Relaying Allergens to Mast Cells via Microvesicles.

Choi HW, Suwanpradid J, Kim IH, Staats HF, Haniffa M, MacLeod AS, Abraham SN.

Science, 2018 Nov 9;362(6415). pii: eaao0666.

- Highlighted: Dangerous liaisons in anaphylaxis. [Science. 2018]

- Highlighted: A Shocking Type of Communication. [Immunity. 2018]

 

13. Mast Cells For the Control of Mucosal Immunity.

Choi HW, Johnson-Weaver B, Staats HF, Abraham SN.

Mucosal Vaccines: Innovation for Preventing Infectious Diseases, 2e, 2019

 

12. Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes.

Arifuzzaman M, Ang WXG, Choi HW, Nilles ML, St John AL, Abraham SN.

Journal of Clinical Investigation Insight, 2018 Sep 20;3(18). pii: 122188.

 

11. In Vitro and In Vivo IgE-/Antigen-Mediated Mast Cell Activation.

Choi HW, Abraham SN.

Methods Mol Biol. 2018;1799:71-80.

 

10. Mast Cell Activators as Novel Immune Regulators.

Johnson-Weaver B, Choi HW, Abraham SN, Staats HF.

Current Opinion in Pharmacology, 2018 Aug; 41:89-95.

 

9. IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense.

Yang B, Suwanpradid J, Sanchez-Lagunes R, Choi HW, Hoang P, Wang D, Abraham SN, MacLeod AS.

Journal of Investigative Dermatology, 2017, 137(5):1166-1175.

 

8. Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules.

Choi HW, Bowen SE, Miao Y, Chan CY, Miao EA, Abrink M, Moeser AJ, Abraham SN.

Immunity, 2016 Dec 20;45(6):1258-1269.

            - Highlighted: Precision Targeting: Mast Cells Wipe Out Infected Bladder Epithelia. [Immunity. 2016]

 

7. Mast Cell Desensitization Inhibits Calcium Flux and Aberrantly Remodels Actin.

Ang WX, Church AM, Kulis M, Choi HW, Burks AW, Abraham SN.

Journal of Clinical Investigation, 2016 Nov 1;126(11):4103-4118.  

 

6. Why Serological Responses during Cystitis are Limited.

Choi HW, Abraham SN.

Pathogens. 2016 Feb 14;5(1). pii: E19.

 

5. Mast cell mediator responses and their suppression by pathogenic and commensal microorganisms.

Choi HW, Abraham SN.

Molecular Immunology, 2015 Jan;63(1):74-9.

 

4. Salmonella Typhimurium Impedes Innate Immunity with a Mast Cell-Suppressing Tyrosine Phosphatase SptP.

Choi HW, Brooking-Dixon R, Neupane S, Lee CJ, Miao EA, Staats HF, Abraham SN.

Immunity, 2013 Dec 12;39(6):1108-20.

            - Highlighted: Salmonella's masterful skill in mast cell suppression. [Immunity. 2013]

 

3. A Mast Cell Degranulation Screening Assay for the Identification of Novel Mast Cell Activating Agents.

Staats HF, Kirwan SM, Choi HW, Shelburne CP, Abraham SN, Leung GY, Chen DY.

Med. Chem. Commun., 2013 Jan 1;4(1):88-94.

 

2. Reactive Oxygen Species Generated by NADPH Oxidase 2 and 4 Are Required for Chondrogenic Differentiation.

Kim KS, Choi HW, Yoon HE, Kim IY.

Journal of Biological Chemistry, 2010 Dec 17;285(51):40294-302.

 

1. Redox-mediated Modification of PLZF by SUMO-1 and Ubiquitin.

Kang SI, Choi HW, Kim IY.

Biochem Biophys Res Commun., 2008 May 16;369(4):1209-14.

Research Topic

Mast cell의 기능과 역할

- Mast cell은 선천성 면역을 담당하는 세포로 알려져 있습니다.

- 인체에 감염이 발생할 때, mast cell의 활성화가 발생합니다. 많은 병원균들이 비만세포의 활성화에 관여하며 이로인해 여러가지 염증 유발 물질을 - 분비합니다. 특히 cytokines의 분비로 다른 면역세포들을 유도해 감염에 대한 방어 작용을 합니다.

- 본 실험실에서는 이러한 mast cell의 활성화에 있어서 특이적으로 발생하는 신호 전달에 관한 연구를 수행하고 있습니다.

- 더불어 여러 감염균들에 대한 mast cell의 역할을 생쥐 모델을 이용하여 연구합니다.

- Mast cell은 여러 다른 면역 세포들과 상호작용을 하는데, 특히 dendritic cell와의 상호작용을 연구합니다.

       * Mast cell activation - Captured by confocal microscope & Scanning Electron Microscope

              

    * Dendritic cell near blood vessels - Captured by two-photon microscope 

              

 

방광 감염(Cystitis)에 발생하는 면역 반응

- 방광의 세균 감염은 한국 국민의 상당수가 감염이 되어 있고 증가 추세에 있습니다. 80% 이상의 방광 감염은 요로계 감염세균(Uropathogenic E.coli)에 의해 발생합니다.

- 방광의 감염균에 의한 병리학적 기전은 구체적으로 알려져 있지 않은 상태입니다.

- 방광에는 상피세포 외에 수많은 선천성 면역세포들이 lamina propria에 존재하고 있습니다. 여기에 존재하는 dendritic cells과 mast cells 및 염증 발생시에 유도되는 monocyte 및 basophil의 역할 및 기능을 연구합니다.

 

학부 수업

면역학I       (Immunology I)

응용면역학 (Applied Immunology)

 

대학원 수업

분자 병리학 (Molecular Pathology)

감염 면역학 (Infection and Immunology)