Tel: 02-3290-3423
Tel: 02-3290-9028
E-mail: sangho@korea.ac.kr
PhD (1989), Department of Anatomy & Human Biology, Division of Biomedical Sciences, King's College, University of London, London, U.K. (Developmental biology)
Rm. 441, Life Sciences Bldg. (Hana Science Hall), Division of Life Sciences,
145 Anam-Ro, Seongbuk-Gu, Seoul 02841 , Korea
[02841, 서울특별시 성북구 안암로 145 고려대학교 생명과학부 하나과학관 A동 304호 ]
e-mail : sangho@korea.ac.kr
Phone : +82-2-3290-3423
Vertebrate development from a fertilized egg to adult form is a dynamic process, involving cleavage, cell proliferation and differentiation. In particular, germ cell lineages and somatic stem cells are fascinating materials for the study of vertebrate embryogenesis and regeneration process upon damage. Among the many critical components involved in stem cell maintenance and differentiation, stem cell niche (microenvironments) is one of the regulatory components in the process. Stem cell niche includes many different molecules consisting of the extracellular matrix and adjacent cell membrane components. It also includes diffusible factors derived from immune responses and diet nutrients from the peripheral blood vessels. The goal is to understand how this highly complex niche may regulate stem cell population including cancer stem cells. By manipulating molecules, cells and tissues, we look into the properties, and functions of the niche questioned. Some of the clues obtained should provide new ways of maintaining, improving and repairing natural stem cell niche, leading to mild treatments of the damaged tissues and insights into cancer prevention and treatments. [Korean]
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