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고려대학교 교수소개

Knowledge & Innovation

소개

홍정호

Prof. 홍정호

Tel:  02-3290-3427

Tel:  02-3290-3629

E-mail: jh_hong@korea.ac.kr

  • About Professor
  • Curriculum Vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

    홍정호 교수 Jeong-Ho Hong

    하나과학관 A동 213호(Office) 220호(Lab)

    Tel. 3290-3427(Office) 3290-3629(Lab)

    E-mail. jh_hong@korea.ac.kr

  • Curriculum

    Education
    • 1992.3.1~1997.8.31 Ph.D. in Pharmacy, Seoul National University, Korea
    • 1990.3.1~1992.2.28 M.S. in Pharmacy, Seoul National University, Korea
    • 1986.3.1~1990.2.28 B.S. in Manufacturing Pharmacy, Seoul National University, Korea
    Career
    • 2006.9.1~present Professor in Department of Life Sciences, Korea University, Korea
    • 2001.3.1~2006.8.31 Post-doctoral fellow in Center for Cancer Research, Massachusetts Institute of Technology, USA
    • 1999.11.22~2001.2.28 Post-doctoral fellow in Dana-Farber Cancer Institute, Harvard Medical School, USA
    • 1999.3.26~1999.11.21 Visiting Scientist in Johns Hopkins University School of Medicine, USA

    • 1997.9.1~1999.8.31 Post-doctoral fellow in Samsung Biomedical Research Institute, Korea
    • 1995.10.1~1996.9.30 Visiting Scientist in the Institute for Virus Research, Kyoto University, Japan
  • Publication

    2015


    • Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation.
    • Hwang JH, Byun MR, Kim AR, Kim KM, Cho HJ, Lee YH, Kim J, Jeong MG, Hwang ES, Hong JH.
    • PLoS One. 2015 Aug 11;10(8):e0135519. doi: 10.1371/journal.pone.0135519. eCollection 2015.

    2014


    • Novel TAZ modulators enhance myogenic differentiation and muscle regeneration.
    • Park GH, Jeong H, Jeong MG, Jang EJ, Bae MA, Lee YL, Kim NJ, Hong JH, Hwang ES.
    • Br J Pharmacol. 2014 Sep;171(17):4051-61. doi: 10.1111/bph.12755.

    • Selenoprotein W enhances skeletal muscle differentiation by inhibiting TAZ binding to 14-3-3 protein.
    • Jeon YH, Park YH, Lee JH, Hong JH, Kim IY.
    • Biochim Biophys Acta. 2014 Jul;1843(7):1356-64. doi: 10.1016/j.bbamcr.2014.04.002. Epub 2014 Apr 12.

    • Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation.
    • Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH.
    • Cell Death Differ. 2014 Jun;21(6):854-63. doi: 10.1038/cdd.2014.8. Epub 2014 Feb 7.

    • Shear stress induced by an interstitial level of slow flow increases the osteogenic differentiation of mesenchymal stem cells through TAZ activation.
    • Kim KM, Choi YJ, Hwang JH, Kim AR, Cho HJ, Hwang ES, Park JY, Lee SH, Hong JH.
    • PLoS One. 2014 Mar 21;9(3):e92427. doi: 10.1371/journal.pone.0092427. eCollection 2014.

    • (-)-Epicatechin gallate (ECG) stimulates osteoblast differentiation via Runt-related transcription factor 2 (RUNX2) and transcriptional coactivator with PDZ-binding motif (TAZ)-mediated transcriptional activation.
    • Byun MR, Sung MK, Kim AR, Lee CH, Jang EJ, Jeong MG, Noh M, Hwang ES, Hong JH.
    • J Biol Chem. 2014 Apr 4;289(14):9926-35. doi: 10.1074/jbc.M113.522870. Epub 2014 Feb 10.

    • FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression.
    • Byun MR, Kim AR, Hwang JH, Kim KM, Hwang ES, Hong JH.
    • Bone. 2014 Jan;58:72-80. doi: 10.1016/j.bone.2013.09.024. Epub 2013 Oct 11.

    • YAP and TAZ regulate skin wound healing.
    • Lee MJ, Ran Byun M, Furutani-Seiki M, Hong JH, Jung HS.
    • J Invest Dermatol. 2014 Feb;134(2):518-25. doi: 10.1038/jid.2013.339. Epub 2013 Aug 9.

    2013


    • Phorbaketal A inhibits adipogenic differentiation through the suppression of PPARγ-mediated gene transcription by TAZ.
    • Byun MR, Lee CH, Hwang JH, Kim AR, Moon SA, Sung MK, Roh JR, Hwang ES, Hong JH.
    • Eur J Pharmacol. 2013 Oct 15;718(1-3):181-7. doi: 10.1016/j.ejphar.2013.08.035. Epub 2013 Sep 12.

    • Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.
    • Jang EJ, Park HR, Hong JH, Hwang ES.
    • J Immunol. 2013 Jun 1;190(11):5764-70. doi: 10.4049/jimmunol.1203403. Epub 2013 Apr 24.

    2012


    • TAZ suppresses NFAT5 activity through tyrosine phosphorylation.
    • Jang EJ, Jeong H, Han KH, Kwon HM, Hong JH, Hwang ES.
    • Mol Cell Biol. 2012 Dec;32(24):4925-32. doi: 10.1128/MCB.00392-12. Epub 2012 Oct 8.

    • Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation.
    • Byun MR, Kim AR, Hwang JH, Sung MK, Lee YK, Hwang BS, Rho JR, Hwang ES, Hong JH.
    • FEBS Lett. 2012 Apr 24;586(8):1086-92. doi: 10.1016/j.febslet.2012.03.008. Epub 2012 Mar 13.

    • Idesolide inhibits the adipogenic differentiation of mesenchymal cells through the suppression of nitric oxide production.
    • Hwang JH, Moon SA, Lee CH, Byun MR, Kim AR, Sung MK, Park HJ, Hwang ES, Sung SH, Hong JH.
    • Eur J Pharmacol. 2012 Jun 15;685(1-3):218-23. doi: 10.1016/j.ejphar.2012.04.018. Epub 2012 Apr 20.

    • TAZ is required for the osteogenic and anti-adipogenic activities of kaempferol.
    • Byun MR, Jeong H, Bae SJ, Kim AR, Hwang ES, Hong JH.
    • Bone. 2012 Jan;50(1):364-72. doi: 10.1016/j.bone.2011.10.035. Epub 2011 Nov 12.

    2011


    • Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells.
    • Lee K, Won HY, Bae MA, Hong JH, Hwang ES.
    • Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9548-53. doi: 10.1073/pnas.1012645108. Epub 2011 May 18.
    • Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation.
    • Rho JR, Hwang BS, Joung S, Byun MR, Hong JH, Lee HY.
    • Org Lett. 2011 Mar 4;13(5):884-7. doi: 10.1021/ol1029386. Epub 2011 Jan 27.

    • Hesperedin promotes MyoD-induced myogenic differentiation in vitro and in vivo.
    • Jeong H, Lee JY, Jang EJ, Lee EH, Bae MA, Hong JH, Hwang ES.
    • Br J Pharmacol. 2011 Jun;163(3):598-608. doi: 10.1111/j.1476-5381.2011.01243.x.

    2010


    • Suppression of adipocyte differentiation by 15-methoxypinusolidic acid through inhibition of PPARγ activity.
    • Lee YS, Sung SH, Hong JH, Hwang ES.
    • Arch Pharm Res. 2010 Jul;33(7):1035-41. doi: 10.1007/s12272-010-0709-0. Epub 2010 Jul 27.

    • TAZ as a novel enhancer of MyoD-mediated myogenic differentiation.
    • Jeong H, Bae S, An SY, Byun MR, Hwang JH, Yaffe MB, Hong JH, Hwang ES.
    • FASEB J. 2010 Sep;24(9):3310-20. doi: 10.1096/fj.09-151324. Epub 2010 May 13.

    • In vivo tumor suppression activity by T cell-specific T-bet restoration.
    • Lee K, Min HJ, Jang EJ, Hong JH, Hwang ES.
    • Int J Cancer. 2010 Nov 1;127(9):2129-37. doi: 10.1002/ijc.25238.

    • Anti-allergic function and regulatory mechanisms of KR62980 in allergen-induced airway inflammation.
    • Won HY, Min HJ, Ahn JH, Yoo SE, Bae MA, Hong JH, Hwang ES.
    • Biochem Pharmacol. 2010 Mar 15;79(6):888-96. doi: 10.1016/j.bcp.2009.10.023. Epub 2009 Nov 5.

    2009


    • Augmentation of PPARgamma-TAZ interaction contributes to the anti-adipogenic activity of KR62980.
    • Jung H, Lee MS, Jang EJ, Ahn JH, Kang NS, Yoo SE, Bae MA, Hong JH, Hwang ES.
    • Biochem Pharmacol. 2009 Nov 15;78(10):1323-9. doi: 10.1016/j.bcp.2009.07.001. Epub 2009 Jul 8.

    • Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone.
    • Min HJ, Won HY, Kim YC, Sung SH, Byun MR, Hwang JH, Hong JH, Hwang ES.
    • Biochem Biophys Res Commun. 2009 Jul 24;385(2):204-9. doi: 10.1016/j.bbrc.2009.05.039. Epub 2009 May 19.

    • Effect of naturally occurring hydroxychavicol acetate on the cytokine production in T helper cells.
    • Min HJ, Nam JW, Yu ES, Hong JH, Seo EK, Hwang ES.
    • Int Immunopharmacol. 2009 Apr;9(4):448-54. doi: 10.1016/j.intimp.2009.01.008. Epub 2009 Feb 7.

    • Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma.
    • Park JW, Min HJ, Sohn JH, Kim JY, Hong JH, Sigrist KS, Glimcher LH, Hwang ES.
    • J Allergy Clin Immunol. 2009 Feb;123(2):479-85. doi: 10.1016/j.jaci.2008.10.035. Epub 2008 Dec 10.

    2008


    • Regulatory mechanisms of IL-2 and IFNgamma suppression by quercetin in T helper cells.
    • Yu ES, Min HJ, An SY, Won HY, Hong JH, Hwang ES.
    • Biochem Pharmacol. 2008 Jul 1;76(1):70-8. doi: 10.1016/j.bcp.2008.03.020. Epub 2008 Apr 6.

    • Isoeleutherin and eleutherinol, naturally occurring selective modulators of Th cell-mediated immune responses.
    • Hong JH, Yu ES, Han AR, Nam JW, Seo EK, Hwang ES.
    • Biochem Biophys Res Commun. 2008 Jun 27;371(2):278-82. doi: 10.1016/j.bbrc.2008.04.060. Epub 2008 Apr 22.

    2007


    • TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
    • Tian Y, Kolb R, Hong JH, Carroll J, Li D, You J, Bronson R, Yaffe MB, Zhou J, Benjamin T.
    • Mol Cell Biol. 2007 Sep;27(18):6383-95. Epub 2007 Jul 16.

    2006


    • TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation.
    • Hong JH, Yaffe MB.
    • Cell Cycle. 2006 Jan;5(2):176-9. Epub 2006 Jan 16. Review.

    2005


    • IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508.
    • Hwang ES, Hong JH, Glimcher LH.
    • J Exp Med. 2005 Nov 7;202(9):1289-300.
    • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.
    • Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB.
    • Science. 2005 Aug 12;309(5737):1074-8.
    • The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members.
    • Mahoney WM Jr, Hong JH, Yaffe MB, Farrance IK.
    • Biochem J. 2005 May 15;388(Pt 1):217-25.

    2004


    • TAZ interacts with TTF-1 and regulates expression of surfactant protein-C.
    • Park KS, Whitsett JA, Di Palma T, Hong JH, Yaffe MB, Zannini M.
    • J Biol Chem. 2004 Apr 23;279(17):17384-90. Epub 2004 Feb 17.

    2003


    • Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.
    • Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR.
    • Mol Cell Biol. 2003 Aug;23(15):5376-87.
  • Research

    본 연구실에서는 아래와 같은 연구들을 진행 중이다.

    1) 중간엽 줄기세포의 증식 및 분화조절에 대한 연구

    • - 중간엽 줄기세포의 증식을 조절하는 세포 신호 전달 물질을 규명하고 이를 활성화시킬 수 있는 약물 및 기술의 개발을 목적으로 한다.
    • - 중간엽 줄기세포의 조골세포, 지방세포 및 연골세포로의 분화를 조절하는 세포 신호 전달 기전을 규명하고 이를 조절할 수 있는 약물 및 세포 치료법의 개발을 목적으로 한다.

    2) 조직 재생 과정의 분자 메커니즘 연구

    • - 근육 재생 과정에서의 근육줄기세포내의 분자세포생물학적 메커니즘을 규명하고 근육줄기세포의 증식 및 활성을 조절하는 기술을 개발하여 근 손상에 대한 세포 치료법의 확립을 목적으로 한다.
    • - 간 재생 과정을 세포 및 분자생물학적 수준에서 연구하여 간 재생의 메커니즘에 대한 보다 자세한 이해를 목적으로 한다.

    3) 근육 및 간에서의 대사과정 조절 인자들의 전사조절 기전 연구

    • - 근육에서의 인슐린 감수성을 조절하는 단백질들의 발현을 유전자 전사조절 수준에서 연구하여 제 2형 당뇨의 치료를 위한 타겟을 제공한다.
    • - 간에서의 콜레스테롤 대사를 조절하는 단백질들의 세포 신호전달 메커니즘을 규명한다.

    4) 대장암 및 전립선암에서의 발암 및 전이 기작에 관한 연구

    • - 대장에서의 발암 기작 및 재생 과정에 대한 분자세포생물학적 기전에 대하여 연구한다.
    • - 전립선암의 전이 과정에 대한 세포 및 분자 수준의 메커니즘을 규명한다.
    • - Organoid culture 기술을 활용하여 발암 기작에 대해 연구한다.
  • Teaching

    학부 강의

    - 유전학, 분자생물학

    대학원 강의

    - 의약생명과학, 분자유전학

  • Lab Members

    Current Members
    • 변미란
    • Ph.D.
    • 연구교수

    • 황준하
    • Ph.D.
    • 연구교수

    • 김아름
    • 석박사통합과정 (박사)

    • 김경민
    • 석박사통합과정 (박사)

    • 박정일
    • 석박사통합과정 (석사)

    • 오호택
    • 석박사통합과정 (석사)
    Former
    • 임형신
    • Ph.D.
    • 한양대학교 약학대학 부교수

    • 박병덕
    • Ph.D.
    • 계명대학교 약학대학 조교수

    • 김선아
    • M.S.
    • Roche

    • 박현진
    • M.S.
    • (주)휴온스

    • 방민수
    • M.S.
    • 아모레 퍼시픽

    • 장은영
    • M.S.
    • LG생활건강

    • 문성아
    • Researcher
    • 서울아산병원

    • 이참한
    • M.S.
    • (주)싸이토젠

    • 성미경
    • M.S.
    • (주)두래

    • 조항준
    • M.S.
    • 케이셀바이오뱅킹 주식회사

    • 이요한
    • M.S.
    • LG생명과학