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고려대학교 교수소개

Knowledge & Innovation

소개

Prof. 고영규

Tel:  02-3290-3453 (office)

Tel:  02-3290-3961 (Lab.)

E-mail: ygko@korea.ac.kr

  • About Professor
  • Curriculum Vitae
  • Publication
  • Research
  • Teaching
  • Lab Members
  • Profile

    ▶ 세포외 공간에서 존재하는 나노튜브 : 본 연구실은 아래 그림과 같이 생쥐 일차 간세포 (mouse primary hepatocytes) 의 세포외 공간에서 세포와 세포를 연결시키는 수많은 나노튜브관을 위상차 현미경으로 최초로 관찰하였음 . 이 관은 액틴 필라멘트와 지질래프트막으로 구성되어 있기 때문에 터널링 나노튜브 (Tunneling Nanotubes,TNT) 라고 함

    ▶ 새로운 연구를 할 것인가 ? : 많은 연구자들은 우연히 TNT 를 관찰하여 왔으나 무시하고 지나쳐 왔음 . TNT 논문을 보고 나서야 “내 실험실도 TNT 를 관찰했었는데 ... ”하면서 후회함 (Bryant, Curr. Biol., 17, R655, 1999). 빈약한 정보와 모든 것을 새롭게 시작하여야 하는 두려움 때문에 많은 연구자들은 더 이상 연구를 진행하지 못하였음 .


    ▶ TNT 연구의 네 가지 핵심 질문들 : 포유동물세포에서 TNT 가 처음 발견된 지 12 년이 지났지만 다음과 같은 네 가지 핵심 질 문들은 해결되지 않고 있음 . 본 실험실은 이 질문에 도전하고 있음 .


    • • TNT 는 어떤 기전으로 형성되는가 ?
    • • TNT 의 구성성분은 무엇인가 ?
    • • TNT 의 생리학적 기능은 무엇인가 ?
    • • TNT 의 의생명학적 응용은 가능한가 ?


    ▶ 터널링 나노튜브 연구센터: TNT 연구의 핵심 질문을 풀기 위해서 열 분의 교수님과 더불어 터널링 나노튜브 연구센터를 운영 중에 있음.

    고영규: 터널링 나노튜브 연구센터 센터장

  • Curriculum

    Education
    • 박사 (1989-1994): 오스틴 소재 텍사스 주립대학 생명과학과
    • 석사 (1985-1987): 고려대학교 생물학과
    • 학사 (1981-1985): 고려대학교 생물학과
    Professional Experiences
    • 2016-현재 : 고려대학교 터널링나노튜브 연구센터 소장
    • 2008-현재 : 고려대학교 생명과학부 교수
    • 2005- 2008: 고려대학교 생명과학부 부교수
    • 2002- 2008: 고려대학교 생명과학부 조교수
    • 1999- 2002: 서울대학교 약학대학 창의연구단 책임연구원
    • 1996- 1999: 서울대학교 의과대학 암연구소 박사후 과정
    • 1994- 1996: Univ. of Texas Southwestern Medical School, 박사후 과정
    수상 경력
    • 석탑강의상 6 회 수상 (2003, 2009, 2010, 2011, 2012, 2013 년 )
    • 우수강의상 3 회 수상 (2010, 2011, 2012 년 )
    • 명강의상 1 회 수상 ( 교육대학원 , 2014 년 )
  • Publication

    My H-index is 36 in Google Scholar and 31 in Web of Science.


    Year 2017

    • 1. Shin, K., Ko, YG and Jeong J (2017) Dexamethasone-induced expression of atrogenes is regulated by Fbxw7b in mouse primary myoblasts. Cell Biology International. 41, 213-220.

    • 2. Lee, HC., Her, NG., …. Ko, YG, and Lee, JS (2017) Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ binding kinase. Cell Death Dis., 8, e2693; doi:10.1038/ccdis.2017.116

    • 3. Yu, D.-M., Jung, S. H., An, H.-T., Hong, J., …., and Ko, Y.-G. (2017) Caveolin-1 deficiency induces cellular senescence with mitochondrial dysfunction. Aging Cell, In press.

    • 4. Jung, SH., Lee HC., Hwang HJ., … Ko, YG., Park, HJ., and Lee, JS (2017) Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCz-p53-p21 signaling pathway. Cell Death Dis. In press

    • 5. Lee, HC., Jung, SH., …. Ko, YG., Gorospe, M., and Lee, JS. (2017) Wig1 dictates Ago2-mediated gene silencing in miRNA-dependent manners. Nucleic Acids Res., In press.

    • 6. Lee, H., Kim, BW, Kim JW, Hong J, Lee, JW, Kim HL, Lee, JS, and Ko, YG (2017) Extracellular reactive oxygen species is generated by cell-surface oxidative phosphorylation complexes. Submitted to Free Radical Biol. Med. Under revision.

    • 7. Lee, H., Park, J. S., Bahn, M.-S., Hong, J., Yu, D.-M., …., and Ko, Y.-G. (2017) Tunneling nanotubes regulate hepatic gluconeogenesis. EMM, Under 2nd revision.

    • 8. Yoon, Y R., Shin, S. W., Ko, Y.-G., Rhyu, I. J., Kim, D.-H., Seong, J. K., and Baik, J.-H. (2017) Glucose-regulated protein 78 binds to and regulates the melnocrotin-4 receptor. Submitted to Diabetes.

    • 9. Lee, H, Yoo, DM, Lee, JS, and Ko, YG (2017) CD133 is an A-kinase anchor protein. Will be submitted to Gastroenterology.

    • 10. Jung, S.-H., Lee, H. C., Park, H. A., Lee, M., Hong, M., Yu, D.-M., Jung, Y. R., kim, Y. N., Ko, Y.-G., Park, H. J., and Lee, J.-S. (2017) Integrin a6b4-Src-Akt signaling induces cellular senescience by counteracting apoptosis in irradiated tumor cells and tissues. Will be submitted to Nat. Cell Biol.


    Year 2016

    • 1. Hwang, H.-J., Jung, S. H., Lee, H. C., Han, N. K., Bae, I. H., Lee, M., Han, Y.-H., Kang, Y.-S., Lee, S.-J., Park, H. J., Ko, Y.-G., and Lee, J.-S. (2016) Idenfication of novel therapeutic targets in the secretome of ionizing radiation-induced senescent tumor cells. Oncology Reports. 35. 841-850.

    • 2. Lee, H., Kim, S.-H., Lee, J.-S., Yang, Y.-H., Nam, J.-M., Lee, J.-S., Kim, B.-W., and Ko, Y.-G. (2016) Mitochondrial oxidative phosphorylation complexes exist in the sarcolemma of skeletal muscle. BMB Reports, 49, 116-121.

    • 3. Jung, SH, Lee, HC, Yu, DM., Kim, BC, Park, SM, Lee, YS, Park, HJ, Ko, Y-G, and Lee, J-S (2016) Haparan sulfation is essential for the prevention of cellular senescence. Cell Death Differ., 23, 417-429.

    • 4 . Hong, J., Park, J.-S., Lee, H., Heong, J.-M., Yun, H. H., Ko, Y.-G * ., and Lee, J.-W * . (2016) Myosin heavy chain is stabilized by BCL-2 interacting cell death suppressor (BIS) in skeletal muscle. Exp. Mol. Med., 48:e225. * co-corresponding author

    • 5. Tan, T., Ko, Y.-G * ., and Ma, J * . (2016) Dual function of MG53 in membrane repair and insulin signaling. BMB Reports, In press. * co-corresponding author

    • 6. Kim, B.-C., Hwang, H.-J., Lee, H., Park, J.-S., Ahn, H. T., Ko, J., Lee, J.-S., and Ko, Y.-G. (2016) Antibody neutralization of cell-surface gC1qR prevents lemellipodia formation and tumorigenesis. Oncotarget. Under revision.

    • 7. Yu, D.-M., Jung, S. H., An, H.-T., Hong, J., …., and Ko, Y.-G. (2016) Caveolin-1 deficiency induces cellular senescence with mitochondrial dysfunction. Under revision in Cancer Res.

    • 8. Lee, H., Park, J. S., Bahn, M.-S., Hong, J., Yu, D.-M., …., and Ko, Y.-G. (2016) Tunneling nanotubes regulate hepatic gluconeogenesis. Under review in Hepatology.


    Year 2015

    • 1 . Jeong, Y.-J., And Jung, M.-G., Son, Y., Jang, J. H., Kim, S. H., Ko, Y.-G., Lee, Y.-S., and Lee, H. J. (2015) Coniferyl aldehyde attenuates radiation enteropathy by inhibiting cell death and promoting endothelial cell function. PLos One, e0128552.

    • 2. Lee, H.-C., Hong, M.-N., Jung, S. H., Kim, B. C., Suh, Y. J., Ko, Y.-G., Lee, Y.-S., Lee, B.-Y., Cho, Y.-G., Myung, S.-H., and Lee, J.-S. (2015) Effect of extremely low frequency magnetic fields on cell proliferation and gene expression. Bioelectromagnetics. 36, 506-516.


    Year 2014

    • 1 . Hong, J., Kim, B.-W., Choo, H.-J., Park, J.-J., Yu, D.-M., Lee, H., Yoon, G., Lee, J.-S., and Ko, Y.-G. (2014) Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation. J. Biol. Chem., 289, 20012-20025. “Recommended in Faculty of 1000Prime”. 8 citations.

    • 2 . Kim, B.-C., Yoo, H.-J., Lee, H.-C., Kang, K.-A., Jung, S.-H., Lee, H.-J., Lee, M., Park, S., Yi, Y.-H., Lee, Y.-S., Ko, Y.-G.* , and Lee J.-S. (2014) Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiation. Oncol. Rep. , 31, 2229-2235. * co-corresponding author

    • 3 . Nguyen, N., Yi, J.-S., Park, H., Lee, J.-S., and Ko, Y.-G. (2014) Mitsugumin 53 (MG5) ligase ubiquitinates focal adhesion kinase during skeletal myogenesis. J. Biol. Chem. , 289, 3209-3216. 7 citations.

    • 4 . Kang, K.-A., Lee, H.-C., Lee, J.-J., Hong, M.-N., Park, M.-J., Choi, H.-D., Kim, Na., Ko, Y.-G.* , and Lee, J.-S.* (2014) Effects of combined radiofrequency radiation exposure on levels of reactive oxygen species in neuronal cells. J. Radiat. Res. , 55, 265-276. * co-corresponding author


    Year 2013

    • 1. Yi, J.-S., Ham, Y.-M., Lee, N.-R., …, Lee, C.-S., Lee, J.-S., Ko, Y.-G. (2013) MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signaling. Nat . Commun . 4:2354 doi: 10.1038/ncomms3354 . 27 citations

    • 2. Yi, J.-S., Moon, D.-K., Park, J.-S., Lee, H., Lee, J.-W., Lee, J.-S., Kim, S.-J., Cho, B.-R., Lee, S.-W.*, and Ko, Y.-G. * (2013) PTRF/Cavin-1 is essential for multidrug resistance in cancer cells. J. Proteome Res. , 12, 605-614. * co-corresponding author. 15 citations.

    • 3. Jung, K.-J., Rho, J.-K., Kim, Y.-M., Jung, J. E., Jin, Y. G., Ko, Y.-G., Lee, J.-S., Lee, J. C., Park, M.-J. (201 3 ) Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells. Oncogene , 32, 209-221. 78 citations.


    Year 2012

    • 1. Kim, B. C., Lee, H. C., Lee, J.-J., Choi, C.-M., Kim, D.-K., Lee, J. C., Ko, Y.-G., and Lee, J.-S. (2012) Wig1 prevents cellular senescence via regulation of p21 mRNA decay through control of RISC recruitment. EMBO J., 31, 4289-4303. 10 citations

    • 2. Park, J.-J., Yi, J. Y., Jin, Y. B., Lee, Y.-J., Lee, J.-S., Lee, Y.-S., Ko, Y.-G.* , and Lee, M.* (2012) Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells. Biochem. Parmacol. , 83, 849-857. * co-corresponding author. 38 citations.

    • 3. Han, N.-K., Kim, B.-C., Lee, H.-C., Lee, Y.-J., Park, M.-J., Chi, S.-G., Ko, Y.-G., and Lee, J.-S. (2012) Secretome analysis of ionizing radiation-induced senescent cancer cells reveals that secreted RKIP plays a critical role in neighboring cell migration. Proteomics, 12, 2822-2832. 12 citations.

    • 4. Park, JJ., Seo, SM., Kim, EJ, and Lee YJ, Ko YG, Ha J, and Lee M. (2012) Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin b1 signaling. Biochem. Biophys. Res. Commun., 426, 461-467. 42 citations.

    • 5. Hong M.-N., Kim, B.-C., Ko, Y.-G., Lee, Y.-S., Hong, S.-C., Kim, T., Pack, J.-K., Choi, H.-D., Kim, N., and Lee, J.-S. (2012) Effects of 837 and 1950 MHz radiofrequency radiation exposure alone or com b ined on oxidative stress in MCF10A cells. Bioelectromagnetics . 33, 604-611 . 9 citations.

    • 6. Lee, M., Park, J.-J., Ko, Y.-G.* , and Lee, Y.-S.* (2012) Cleavage of ST6Gal I by radiation-induced BACE1 inhibits Gogi-anchored ST6Gal-mediated sialyation of integrin b1 and migration in colon cancer cells. Radiation Oncology , 7, 47. * co-corresponding author. 8 citations.

    • 7. Park, J.-J., Jin, Y. B., Lee, Y.-J., Lee, J.-S., Lee, Y.-S., Ko, Y.-G.* , and Lee, M.* (2012) KAI1 suppresses HIF-1a and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer. BMC Cancer . 12, 81. * co-corresponding author. 14 citations

    • 8. Hong, M.-N., Kim, B.-C., Ko, Y.-K., Lee, Y.-S., Hong, S.-C., Kim, T., Pack, J.-K., Choi, H.-D., and Lee, J.-S. (2012) Effects of combined radiofrequency radiation exposure on the oxidative stress. Bioelectromagnetics . 53, 79-86. 9 citations.

    • 9. Kim, S., Seo, J., Ko, Y.-G., Huh, Y.-D., and Park, H. (2012). Lipid-binding properties of TRIM72. BMB Reports . 45, 26-31.


    Year 2011

    • 1. Kim, K.-B., Lee, J.-H., Yi, J.-S., Yoo, D.-M., Kwon, Y.-C., Ahn, B.-Y., Cho, H. Kim, Y.-K., Yoo, H.-J., Lee, J.-S., and Ko, Y.-G . , (2011) Cell surface gC1qR is a key regulator for lamellipodia formation and cancer metastasis. J. Biol. Chem. , 286, 23093-23101. “A paper of the week” . 25 citations

    • 2. Kim, J.-H., Kim, H., Yoon, Y.-S., Xu, W., Yoon, J.-K., Choi, S.-E., Ko, Y.-G. , Kim, M.-J., Lee, S.-J., Wang, H.-J., Yoon, G. (2011) Involvement of mitophage in o n cogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency. Autophagy . 7, 1187-1198. 48 citations.


    Year 2010

    • 1. Lee, J.-J., Lee, J.-W., Ko, Y.-G . , Hong, S. I., and Lee, J.-S. (2010) Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species. Oncogene , 29, 561-575. 34 citations.

    • 2. Park, E.-Y., Kwon, O.-B., Joen, B. C., Lee, C.-S., Ko, Y.-G.* and Song, H.-K. * (2010) Crystal structure of PRY-SPRY domain of human TRIM72. Proteins (IF=2.813) . 78, 790-795. * co-corresponding author. 22 citations.

    • 3. Kim, K.-B., Byun, H.-O., Han, N.-K., Ko, Y.-G. , Choi, H.-D., Kim, N., Pack, J.- K., and Lee, J.-S. (2010) Two-dimensional electrophoretic analysis of radio frequency readiation-exposed MCF7 breast cancer cells. J. Radiol. Res. , 51, 205-213. 21 citations.

    • 4. Lee, C.-S., Ham, Y.-M., Kim, B.-W., Kwon, O.-B., Choo, H.-J., Jang, S.-Y., Chi, S.-G., Kim, J.-Y., Kim, J.-H., and Ko, Y.-G. (2010) TRIM72 negatively regulates myogenesis by targeting insulin receptor substrate-1. Cell Death Differ . , 17, 1254-1265. 35 citations.

    • 5. Jung, S.-Y., and Ko, Y.-G. (2010) TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Biochem. Biophys. Res. Commun. , 396, 238-245. 16 citations.

    • 6. Kim, B.-W., Lee, J.-W., Choo, H.-J., Lee, C.-S., Jung, S.-Y., Yi, J.-S. ..., and Ko, Y.-G. (2010) Mitochondrial oxidative phosphorylation system is recruited to detergent-resistant lipid rafts during myogenesis. Proteomics , 10, 2498-2515. “Cover paper” . 17 citations.

    • 7. Kim, J., Ahn, S., Ko, Y.-G. , Boo, Y.-C., Chi, S.-G., Ni, C.-W., Go, Y.-M., and Park, H. (2010) X-lined inhibitor of apoptosis protein controls integrin {alpha}5-mediated cell adhesion and migration. Am. J. Physiol. Hear Circ. Physiol. . 299, H300-309 . 18 citations.

    • 8. Kim, B.-W., Lee, C.-S., Yi, J.-S., Lee, J.-W., Choo, H.-J., Jung, S.-Y., ....., and Ko, Y.-G. (2010) Novel biological insights from lipid raft proteomics; the mitochondrial oxidative phosphorylation system is associated with detergent- resistant lipid rafts. Expert Rev. Proteomics , 7, 849-866 . 16 citations.


    Year 2009

    • 1. Kim, K.-B., Kim, B.-W., Choo, H.-J., Kwon, Y.-C., Ahn, B.-Y., Choi, J.-S., Lee, J.-S., and Ko, Y.-G. (2009) Proteome analysis of adipocyte lipid rafts reveals that gC1qR plays essential roles in adipogenesis and insulin signal transduction. Proteomics, 9, 2373-2382. “Selected in the issue” 31 citations

    • 2. Byun, H.-O., Han, N.-K., Lee, H.-J., Kim, K.-B., Ko, Y.-G. , Yoon, G., Lee, Y.-S., Hong, S.-I., and Lee, J.-S. (2009) Cathepsin D and eukaryotic translation elongation factor 1 as markers of stress-induced premature senescence. Cancer Res. , 69, 4638-4637 . 56 citations.

    • 3. Yi, J.-S., Choo, H.-J., Lee, C.-S., Kim, H.-M., Cho, B.-R., Ham, Y.-M., and Ko, Y.-G. (2009) Ginsenoside induces ligand-independent Fas activation via lipid raft disruption. Biochem. Biophys. Res. Commun. (IF=2.595) , 385, 154-159 . 39 citations.

    • 4. Kim, K. M., Cho, H., Choi, K., Kim, J., Kim, B.-W., Ko, Y.-G. , Jang S. K., and Kim, Y. K. (2009) A new MIF4G domain-containing protein PIROT directs the pioneer round of translation. Genes Develop. (IF=12.889), 23, 2033-2045 . 54 citations.


    Year 2008

    • 1. Kim, H.-M., Choo, H.-J., Ko, Y.-G. , Jeon, S.-J., Kim, C. H., Joo, T., and Cho, B.-R. (2008) Two-photon fluorescent probes for lipid raft imaging. Effect of chain length. ChemBioChem. 9, 2830-2838 . 19 citations.

    • 2. Lee, J. J., Kwak, H.-J., Lee, Y.-M., Park, M.-J., Ko, Y.-G. , Choi, H.-D., Kim, N., Pack, J.-K., Hong, S.-I., and Lee, J.-S. (2008) Radiofrequency radiation does not affect cell cycle, cellular migration, and invasion. Bioelectromagnetics, 29,615-625 . 13 citations.

    • 3. Lee, S.-J., Choi, D., Rhim, H., Choo, H.-J., Ko, Y.-G. , Kim, C.-G., and Kang S. (2008) PHB2 interacts with RNF2 and represses CP2c-stimulated transcription. Mol. Cell Biochem. , 319, 69-77. 9 citations.

    • 4. Choo, H.-J., Kim, B.-W., Kwon, O.-B., Lee, C.-S., Choi, J.-S. and Ko, Y.-G. (2008) Secretion of adenylate kinase 1 is required for extracellular ATP synthesis in C2C12 myotubes. Exp. Mol. Med. , 40, 220-228. 11 citations.

    • 5. Kim, K.-B., and Ko, Y.-G. (2008) Isolation of detergent-resistant lipid rafts for proteomic analysis. Methods Mol. Biol. 424, 413-422. 24 citations.


    Year 2007

    • 1. Kim, H.-M., Fang, X. Z., Yang, P. R., Yi, J.-S., Ko, Y.-G. , Piao, M. J., Chung, Y. D., Park, Y. W., Jeon, S.-J., and Cho, B.-R. (2007) Design of molecular two-photon probes for in vivo imaging 2H-Benzo [h]chromene-2-one derivatives. Tetrahedron Lett. 48, 2791-2795 . 44 citations.

    • 2. Kim, H.-B., Yang, P. R., Seo, M. S., Yi, J.-S., Hong, J. H., Jeon, S.-J., Ko, Y.-G. , Lee, K. J., and Cho, B. R. (2007) Magnesium ion selective two-photon fluorescent probe based on a Benzo[h] chromene derivative for in vivo imaging. J. Org. Chem. , 72, 2088-2096 . 100 citations.

    • 3. Kim, H.-M., Choo, H.-J., Jung, S.-Y., Ko, Y.-G. , Park, W.-H., Jeon, S.-J., Kim, C. H., Joo, T., and Cho, B. R. (2007) A two-photon fluorescent probe for lipid raft imaging: C-laurdan. ChemBioChem, 8, 553-559. 133 citations.

    • 4. Kim, H. M., Jung, C., Kim, B. R., Jung, S.-J., Hong, J. H., Ko, Y.-G. , Lee, K. J., and Cho, B. R. (2007) Environment-sensitive two-photon probe for intracellular free magnesium ions in live tissue. Angew. Chem. Int. Ed. , 46, 1-5 . 99 citations.

    • 5. Jin, J.-K., Ahn, B.-H., Na, Y.-J. Kim, J.-I., Kim, Y.-S., Choi, E.-K., Ko, Y.-G. , Chung K. C., Kozlowski, P. B., and Min, D. S. (2007) Phospholipase D1 is associated with amyloid precursor protein in Alzheimer’s disease. Neruobiol. Aging , 28, 1015-1027 . 29 citations.


    Year 2006

    • 1. Park, S. G., Kang, Y. S., Kim, J. Y., Lee C. S., Ko, Y.-G. , Lee, W. J., Lee, K.-U., Yeon, Y. I., and Kim, S. (2006) Hormonal activity of AIMP/p43 for glucose homeostasis. Proc. Nat’l. Acad. Sci. U. S. A . , 103, 14913-14918 . 49 citations.

    • 2. Kim, S.-I., Yi, J. S., and Ko, Y.-G. (2006). Amyloid b oligomerization is induced by brain lipid rafts. J. Cell. Biochem., 99, 878-889. 75 citations

    • 3. Choo, H.-J., Kim, J.-H., Kwon, O.-B., Lee, C. S., Lee, J. Y., Han, S. S., Youn, Y.-S., Yoon G., Choi, K.-M., and Ko, Y.-G. (2006) Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabeteologia. 49, 784-791. “Introduced in commentary section” . 216 citations.

    • 4. Kim, K.-B., Lee, J.-W., Jung, S.-Y., Chi, S.-G., and Ko, Y.-G. (2006) Oxidation-reduction respiratory chains and ATP synthase complex are localized in the lipid rafts originating from plasma membrane. Proteomics , 6, 2444-2453. “Cover paper” . 81 citations .

    • 5. Rhee K. H., Nam, K. H., Lee W. H., Ko, Y.-G. , Kim, E. E., and Hwang K.-Y. (2006) Expression, purification, and preliminary X-ray crystallographic analysis of the complex G(alphai3)-RGS5 from human with GDP/Mg2+/AlF4-. Protein Pept. Lett., 13, 945-949


    Year 2005

    • 1. Yi, J.-S., Kim, J.-H., Park, S. G., Kim, S., and Ko, Y.-G. (2005) Aminoacyl-tRNA synthetase-interacting multi-functional protein, p43, is imported to endothelial cells via lipid rafts. J. Cell. Biochem., 96, 1286-1295 . 8 citations.

    • 2. Park, Y.-K., Lee, J.-W., Ko, Y.-G. , Hong, S., and Park, S.-H. (2005) Lipid rafts are required for efficient signal transduction by CD1d. Biochem. Biophys. Res. Commun. , 327, 1143-54. 30 citations.


    Year 2004

    • 1. Kim, B.-W., Choo, H.-J., Lee, J.-W., Kim, J.-H., and Ko, Y,-G. (2004) Extracellular ATP is generated by ATP synthase complex in adipocyte lipid rafts. Exp. Mol. Med. , 36, 476-85. 117 citations

    • 2. Kim, K.-B., Kim, S.-I., Choo, H.-J., Kim, J.-H., and Ko, Y.-G. (2004) Two dimensional electrophoretic analysis reveals that lipid rafts are intact at physiological temperatures. Proteomics , 4, 3527-35. 35 citations.

    • 3. Bae, T.-J., Kim, M.-S., Kim, J.-W., Kim, B.-W., Choo, H.-J., Lee, J.-W., Kim, K.-B., Lee, C.-S., Kim, J.-H., Chang, S. Y., Kang, C.-Y., Lee, S.-W., and Ko, Y.-G. (2004) Lipid raft proteome reveals ATP synthase complex in the cell surface. Proteomics , 4, 3536-48. 1 57 citations


    Year 2003

    • 1. Han, J., Lee, C.-S., Yun, C.-Y., Lee, B.-H., Ko, Y.-G. , Kang, C.-S., Lee, S.-D., Hwang, J.-S., Kang, S.-W., and Kim, H.-R. (2003) Cloning and expression of male-specific protein (MSP) from the hemolymph of greater wax moth, Galleria mellonella L. Arch. Insect. Biochem. Physiol. 54, 110-120. 10 citations.


    Year 2002

    • 1. Park, H., Park, S. G., Kim, J., Ko, Y.-G. , and Kim, S. (2002) Signaling pathways fo TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43. Cytokine 20, 148-153 . 61 citations.

    • 2. Park, H.-S., Cho, S.-G., Kim, C.-K., Hwang, H.-S., Noh, K.-T., Kim, M.-S., Huh, S.-H., Kim, M.-J., Ryoo, K., Kim, E.-K., Kang, W.-J., Lee, J.-S., Seo, J.-S., Ko, Y.-G. , Kim, S., and Choi, E.-J. (2002) Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol. Cell. Biol. 22, 7721-7730 . 162 citations.

    • 3. Park, S. G., Kang, Y.-S., Ahn, Y. H., Lee, S. H., Kim, K. R., Kim, K. W., Koh, G.-Y., Ko, Y.-G. ., and Kim, S. (2002) Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. J. Biol. Chem. 277, 45243-45248 . 134 citations.

    • 4. Ko, Y.-G. , Park, H., and Kim, S. (2002) Novel regulatory interactions and activities of mammalian tRNA synthetases . Proteomics 2, 1304-1310. 35 citations.

    • 5. Kim, J.-Y., Kang, Y.-S., Lee, J.-W., Kim, H-J., Ahn, Y. H., Park, H., Ko, Y.-G. , and Kim, S. (2002). p38 is essential for cellular stability of macromolecular tRNA synthease complex and viability of mice. Proc. Nat’l. Acad. Sci. U. S. A. 102, 7912-1916 . 99 citations.


    Year 2001

    • 1. Ko, Y.-G. , Kang, Y.-S., Park, H., Seol, W., Kim, J., Kim, T., Park, H.-S., Choi, E.-J. and Kim, S. (2001) Apoptosis signal-regulating kinase 1 controls the proapoptotic function of Daxx in the cytoplasm. J. Biol. Chem. 276, 39103-39106. 124 citations .

    • 2. Ko, Y.-G. , Park, H., Kim, T., Lee, J.-W., Park, S. G., Kim, J. E., Seol, W., Lee, W.-H., Park, J.-E., and Kim, S. (2001) A cofactor of tRNA synthetase is released to upregulate proinflammatory chemokines and enriched in atherosclerosis lesions. J. Biol. Chem. 276, 23028-23033. 134 citations .

    • 3. Ko, Y.-G. Kim, E.-K., Park, H., Kim, T, Park, H.-S., Choi, E.-J., and Kim, S. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem . 276, 6030-6036. 139 citations


    Year 2000

    • 1. Kang, J.-W., Kim, T., Ko, Y.-G., Rho, S. B., Park, S. G., Kim, M. J., Kwon, H. J., and Kim, S. (2000) Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. J. Biol. Chem. 275, 31682-31688. 36 citations.

    • 2. Lee, C.-Y., Lee, J.-S., Ko, Y.-G., J.-I. Kim, and Seo, J.-S. (2000) Hsp70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation. J. Biol. Chem. 275, 25665-25671. 460 citations.

    • 3. Kim, T., Park, S. G., Kim, J. E., Seol, W., Ko Y.-G. * , and Kim, S. (2000) Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex. J. Biol. Chem. 275, 21768-21772. * Corresponding author . 39 citations.

    • 4. Park, W.-Y., Park, J.-S., Cho, K.-A., Kim, D.-I., Ko, Y.-G., Seo, J.-S., and Park, S.-C. (2000) Up-regulation of caveolin attenuates EGF signaling in senescent cells. J. Biol. Chem. 275, 20847-20852. 189 citations.

    • 5. Ko, Y.-G. , Kang, Y.-S., Kim, E.-K., Park, S.-K., and Kim, S. (2000) Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. J. Cell Biol . 149 , 567-574. 87 citations .

    • 6. Lee, S. W., Ko, Y.-G., Bang, S. H., Kim, S., and Kim, K-S. (2000) Death effector domain of a mammalian apoptosis mediator, FADD, induces bacterial cell death. Mol. Microbiol . 35 , 1540-1549. 20 citations.

    • 7. Ko, Y.-G. , Kang, Y.-S., and Seo, J.-S. (2000) Caveolin-1 internalization by heat shock or hyperosmotice shock. Exp. Cell Res . 255 , 221-228. 36 citations.


    Year 1999-1988

    • 1. Ko, Y.-G. , Lee, J.-S., Kang, Y.-S., Ahn, J.-H., and Seo, J.-S. (1999) TNF-alpha-mediated apoptosis is initiated in caveolae-like domains. J. Immunol ., 162, 7217-7223 . 143 citations .

    • 2. Ahn J.-H., Ko, Y.-G., Park, W.-Y., Kang, Y.-S., Chung, H.-Y. and Seo, J.-S. (1999) Suppression of ceramide-mediated apoptosis by HSP70 . Mol. Cells 9 , 200-206 . 51 citations.

    • 3. Ko, Y.-G. , Liu, P., Pathak, R. K., Craig, L., and Anderson, R. G. W. (1998) Early effects of pp60v-src kinase activation on caveolae. J. Cell Biochem . 71 , 524-535. 41 citations.

    • 4. Liu, P., Ying, Y., Ko, Y.-G., and Anderson, R. G. W. (1996) Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae. J. Biol. Chem . 271 , 10299-10303. 391 citations.

    • 5. Thompson G. A. Jr., Morita, N., Okuyama, H., Kim, Y., Ko, Y.-G., and Hung, C.-Y. On the presence of glycosylphosphatidylinositol-anchored proteins in plants. Plant Lipid Metabol., 227-229, 1995. 1 citations.

    • 6. Ko, Y.-G. , Hung, C.-Y., and Thompson, G. A. Jr. (1995) Temperature regulation of the Tetrahymena mimbres glycosylphosphatidylinositol-anchored protein lipid composition. Biochem. J. 307, 115-121 . 14 citations.

    • 7. Hung, C.-Y., Ko, Y.-G. , Thompson, G. A. Jr. (1995) Temperature-induced alteration of inositolphosphorylceramides in the putative glycosylated lipid precursors of Tetrahymena mimbres glycosylphosphatidylinositol-anchored proteins. Biochem. J . , 307, 107-113. 10 citations.

    • 8. Ko, Y.-G. , and Thompson, G. A. Jr. (1995) Purification of glycosylphosphatidylinositol-anchored proteins by modified Triton X-114 partitioning and preparative gel electrophoresis. Anal. Biochem . 224, 166-172. 42 citations.

    • 9. Ko, Y.-G. , and Thompson, G. A. Jr. (1992) Immobilization antigens from Tetrahymena thermophila are glycosylphosphatidylinositol-linked proteins. J. Protozool . 39 , 719-723. 25 citations.

    • 10. Ko, Y.-G. , and Kim, H.-R. (1988) Purification, characterization and synthesis of vitellin from thecabbage butterfly, Pieris rapae L. Korean Biochem. J . 21 , 471-478.

    • 11. Yeo, J.-W., Ko, Y.-G., and Kim H.-R. (1988) Some characteristics of hemolymph yolk protein in Pieris rapae L. Korean J. Entomol . 18 , 27-34.

    • 12. Kim, H.-R., Ko, Y.-G., and Mayer (1988) Purificaton, characterization and synthesis of vitellin from the cabbage butterfly, Pieris rapae L. Arch. Insect Biochem. Physiol . 9 , 67-79. 13 citations.


    Patents

    • 1. Young-Gyu Ko, Jae-Sung Yi, Chang-Seok Lee (2013) Use of TRIM72 as a target for muscle and heart enhancer. European Patent. Patent No., EP 2 185 174 B1. Date of Patent: Mar. 16, 2016

    • 2. 고영규 (2014) MG53-UBE2H 상호작용을 이용한 제 2형 당뇨 치료제의 스크리닝 방법. 국내특허 제 10-1460737호. 등록일2014년 11월 5일

    • 3. Young-Gyu Ko, Jae-Sung Yi, Chang-Seok Lee (2013) Use of TRIM72 as a target for muscle and heart enhancer. United States Patent. Patent No., US 8,383,602 B2. Date of Patent: Feb. 26, 2013

    • 4. 고영규 (2013) 층상 위족 형성 및 암 전이 조절용 조성물. 국내특허 제 10-1282374호. 등록일2013년 6월 28일

    • 5. 고영규, 이재성, 이창석 (2013) 근육 및 심장 강화제의 타겟으로서 TRIM72의 용동. 국내특허 제 10-10483164호. 등록일2011년 7월 5일

    • 6. Sunghoon Kim and Young-Gyu Ko (2006) Method of inducing production of IL-8 or TNF by in vitro administration of an N-terminal polypeptide of p43. United States Patent. Patent No., US 7,037,505 B2. Date of Patent: May 2, 2006

  • Research

    Research Area

    원형질막에 호르몬 수용체와 신호전달물질들이 제멋대로 흩뜨려져 있다면 세포신호전달은 느리고 비효율적으로 일어날 것이다 .

    따라서 원형질막에는 신호전달물질들을 조직적으로 모아서 세포신호전달의 중심지로 작용하는 지질래프트 (lipid rafts) 가 존재한다 .

    본 연구실은 지질래프트의 비교 단백질체학으로 당뇨병 , 근육병 , 노화 , 암 등의 원인이 될 수 있는 신규 신호전달단백질들을 동정하였다 .

    이들 지질래프트 단백질들의 기능을 이해하기 위해서 아데노바이러스 , siRNA, 유전자 적중생쥐 등 최신의 분자세포생물학적 실험기법을 사용하고 있다 . 특히 근육분화 동안 발현되기 시작하는 TRIM72/MG53 가 IRS-1 의 유비퀴티네이션을 유도하여 근육분화를 음성적으로 조절하기 때문에 TRIM72/MG53 적중 생쥐에서 인슐린저항성이 사라짐을 증명하였다 .

    더불어 암세포 , 노화세포 , 지방세포 , 근육세포에서 특이적으로 발현되는 지질래프트 단백질들을 다수 동정하여 이들 단백질들의 기능을 연구하고 있다 .

    본 연구실은 지질래프트 연구를 수행하는 중 지질래프트 단백질인 CD133 이 터널링나노튜브 (TNT) 의 형성에 중요한 역할을 수행한다는 것을 증명하였다 . 현재 CD133 에 의해서 만들어진 TNT 의 생물학적 기능연구에 모든 인적 - 물적 자원을 쏟아 붓고 있다 .

    최근 사이언스 학술지는 지질래프트 분야를 미래의 노벨상 분야로 선정하였다 (Mysteries of the Cell. Science, 334, 1046-1051, 2011).

    Ongoing Project
    • • 선도연구센터 지원사업 터널링 나노튜브 연구센터 ( 센터장 , 고영규 ): 2015-2022, 13 억 / 년
    • • 인슐린 저항성 치료제로서 MG53-IRS-1 결합억제제의 개발 ( 연구책임자 , 고영규 ): 204-2019, 5 억 / 년
  • Teaching

    • • 생리학I(전공과목): 석탑강의상 7회 수상 (2003, 2009, 2010, 2011, 2012, 2013, 2016년), 우수 강의상 1회 수상(2014)
    • • 생리학(교육대학원): 명강의상 1회 수상(2014년)
    • • 생명공학과 미래사회(핵심교양과목): 우수강의상 3회 수상 (2010, 2011, 201, 2014년)
    • • 일반생물학
  • Lab Members

    Current

    • • Dr. Lee, Sungsoo(연구교수, Ph. D. from URI.)
    • • Dr. Kim, Bong-Woo(연구교수, Ph. D. from Korea Univ.)
    • • Dr. Lee, Hyun(박사후 과정, Ph. D. from Korea Univ.)
    • • Yoo, Dong-Min(박사후 과정, Ph. D. from Korea Univ.)
    • • Park, Jun Seob(석박사 통합과정)
    • • Kim, Ki-Tae(석사과정)
    • • Lee, Hwa-Yeon(석사과정)
    • • Yoon,Seo-Yeon(석사과정)
    • • Byun,Jo-Hyeun(석사과정)
    • • Eom,Min-Ji(석사과정)
    • • Seo, Young-Yee(터널링나노튜브 연구센터 행정직원)


    Former

    • • Dr. Lee, Je-Jung:
    • • Dr. Kim, Bum-Chan: Samsung Inc.
    • • Hong, Jin: Postdocter in Baylor University
    • • Dr. Jung-Jin Park: Research Professor in Chungbuk Nat’l Univ.
    • • Dr. Nga Nguyen: A professor in Vietnam
    • • Dr. Joong-Won Lee: Postdocter in Scripps Inistitute
    • • Dr. Hyo-Jung Choo: Postdocter in Emory Univ.
    • • Dr. Jae-Sung Yi: Postdoctor in Yale Univ.
    • • Dr. Young-Mi Ham: Postdoctor in Harvard Univ.
    • • Ji-Yoen Lee (M. S.): 농업진흥연구소 연구원
    • • Dr. Tae-Jung Bae: Postdocter in USA
    • • Jun-Woo Kim (M. S.): LG 생명과학 연구원
    • • Dr. Soon-Young Jang: Postdocter in Yonsei Univ. Medical School
    • • Chan-Woong Park (M. S.): 생명공학연구소 연구원
    • • Joo-Hyung Lee (M. S.): 박사후과정생, Baylor Univ.
    • • Na-Rae Lee (M. S.): 유한양행 연구원
    • • Kim, Seung-Hyub: 경희대 치과대 학생
    • • Hwang, Hyun-Jeong (M. S.): 박사과정, Inha Univ
    • • Lee, Jeong-Woo (M. S.): 변리사
    • • Ban, Myong-Seok: 병역특례 근무중
    • • Choi, Bo-Woon: